Abstract
Natural products are often a source for bioactive compounds which have great potential for developing novel therapeutic agents. In this sense, the present study aimed to formulate and evaluate a gel containing Morus nigra leaf extract and to evaluate its anti-inflammatory (in-vivo) and antioxidant (in-vitro) activity. The anti-inflammatory activity was evaluated using Carrageenan-induced paw oedema. The antioxidant activity is evaluated by the lipid peroxidation inhibition and DPPH radical scavenging method. The results indicated that the extract (oral and topical route) and the blackberry gel (topical route) produced a significant anti-inflammatory activity (p < 0.05) compared to the untreated control, and similar to the reference drugs (ibuprofen and diclofenac). Regarding antioxidant activity, the Morus nigra extract also showed a significant activity in the tested models. Based on the above observations and results, mora gel formulation was found to be a promising anti-inflammatory formulation and further extensive in-vitro and in-vivo studies are warranted to evaluate its safety and biological potency and which may be useful for further clinical applications.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
