Abstract
The aim of this study was to evaluate anti-hypoxia activity of polyphenolic extracts of Crataegus microphylla and Crataegus pentaegyn on mice. Three experimental models of hypoxia were considered, including asphyctic hypoxia, haemic hypoxia, and circulatory hypoxia. Polyphenolic extract of both plants exhibited significant anti-hypoxic activity and prolonged animal survival time. Anti-hypoia activity of C. pentaegyn was found to be superior to that of C. microphylla in circulatory and asphyctic hypoxia. Antihypoxic activity of these extracts may be attributed to their phenolic compounds.
Highlights
Hypoxia, a state of oxygen deficiency, occurs in a number of human diseases, including heart diseases, ischemia, bleeding and heart attack
Elburensis (CP) and C. microphylla (CM) fruits were collected from Mazandaran forests in autumn 2012, dried at room temperature, and
Antioxidant activity of herbal extracts has been attributed to the presence of phenolic compounds (Ebrahimzadeh et al, 2008)
Summary
A state of oxygen deficiency, occurs in a number of human diseases, including heart diseases, ischemia, bleeding and heart attack. Hypoxia causes several deleterious effects, which may lead to tissue destruction and death (Kiang, Tsen, 2006). Hypoxia mediates the production of nitric oxide, which in turn provokes lipid peroxidation and cell membrane injury (Kiang, Tsen, 2006). Hypoxia can induce ROS(reactive oxygen species) production, as well (Armstrong, 2010). Antioxidants have been proven to scavenge ROS and are able to exhibit antihypoxia property. Plants are considered as a valuable source of natural antioxidants. (Rosaceae)] is one of the oldest medicinal plants that is widely used throughout the world, especially in South European countries and Turkey (Bahorun et al, 2003, Barros, Carvalho, Ferreira, 2011). Crataegus spp. is mainly used for treatment of cardiovascular diseases
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