Abstract
Arterial hypertension is associated with elevated risk of cognition decline and vascular dementia development, as the Alzheimer disease development. Therefore, antihypertension therapy might be of preventive value. The review is focused on literary data that witness on, despite controversial, evidence of cerebroprotective action of the range of antihypertension medications. Especially, dihydropyridine calcium antagonists, diuretics and some blockers of renin-angiotensin-aldosterone system. These act not only via blood pressure decrease, but due to additional specific neuroprotective mechanisms. This makes it to consider calcium antagonists and diuretics as a major component of systemic hypertension management, incl. elderly and senile patients, aiming to prevent cognition decline and dementia of various types development.Nitrendipine, among the calcium channels antagonists, and indapamide among diuretics have acquired the broadest evidence that points on their cerebroprotective properties.
Highlights
Нитрендипин среди антагонистов кальция и индапамид среди диуретиков обладают наибольшей доказательной базой, свидетель ствующей о наличии у них выраженных церебропротективных свойств
Arterial hypertension is associated with elevated risk of cognition decline and vascular dementia development, as the Alzheimer disease development
Antihypertension therapy might be of preventive value
Summary
Нитрендипин среди антагонистов кальция и индапамид среди диуретиков обладают наибольшей доказательной базой, свидетель ствующей о наличии у них выраженных церебропротективных свойств. Результаты показали, что снижение когнитивных функций было ниже при лечении АГ — относительный риск (ОР) — 1,9; 95% доверительный интервал (ДИ) 0,8-4,4, чем у пациентов с АГ, не принимающих АГП — ОР 4,3; 4,9%, ДИ 2,1-8,8.
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