Abstract
Previous studies have found that banana flowers, leaves, pseudostems, roots, infructescence stalks, and peels (M. paradisiacal (Linn.)) have antihyperglycemic effect. The banana peel (Musa nana Lour.) might have the antihyperglycemic activity, its antihyperglycemic activity and active ingredients remain to be elucidated. In this paper, fresh banana peel was sequential extraction using solvents with decreasing polarity. Then, the ethyl acetate and petroleum ether extracts (EBP and PBP) were chosen to evaluate the antihyperglycemic activity in alloxan-induced diabetic mice. And the antihyperglycemic activity guided fractionation of compounds. The EBP displayed potent antihyperglycemic activity. lupenone and -sitosterol were separated from EBP. Animal experiments results indicated that lupenone could effective reduce blood glucose of diabetic mice. The banana peel and its ingredient lupenone showed promising antihyperglycemic activity. The banana peel could be utilized as a natural source of antihyperglycemic food, health care or drug and lupenone has potential to develop as an antihyperglycemic drug.
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