Abstract
PROLONGED administration of gonadotropic hormones derived from one species to an individual of a different species can elicit formation of substances in the plasma capable of preventing the action of the administered hormones. These substances have been named antihormones, or more specifically, antigonadotropins. Such terminology infers a similarity between antihormone and antibody formation; however, it is not the purpose of this report to consider the immunological properties of antihormones. This subject has been amply reviewed by Zondek and Sulman (1). Antigonadotropins, besides being effective against the administered hormone, may also be effective against other gonadotropic hormones. In experimental animals, it has been demonstrated that nonspecific antigonadotropins may even be effective against the normal, circulating gonadotropins. For example, Rowlands (2) found that nonspecific antihormones were formed in the serum of rabbits injected with an ox anterior pituitary extract. Administration of thi...
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