Abstract
Antihistamines (AGP) prevent histamine action by blocking H1 receptors which determines their wide use in allergic rhinitis (AR). The author provides an overview of scientific articles, clinical and experimental studies on various aspects of AGP: pharmacokinetics, indications for administration in ENT practice, efficiency and safety. The authors analyzed the practicability of antihistamines application in the treatment of severe and moderate persistent AR, including combinations with topical steroids and leukotriene antagonists. We describe the benefits of desloratadine, the active metabolite of loratadine. The numerous experimental and clinical studies of desloratadine have proven antioxidant effect, anti-inflammatory effect, significant effect on nasal congestion, rhinorrhea, and the severity of eye symptoms of AR. In one of these studies, ACCEPT2, it was presented that desloratadine provides a proven long-lasting effect even in severe persistent perennial rhinitis, thus confirming the absence of addiction to this preparation.
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