Abstract
Antigenotoxic activity of allicin, one of the sulphur compounds of garlic (Allium sativum) which possesses antioxidant and thiol disulphide exchange activity, was studied against estradiol-17β-induced genotoxic damage using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) as parameters. Approximately 10, 20 and 40 µM of estradiol-17β was tested for its genotoxic effect in the presence of metabolic activation and was found to be genotoxic at 20 and 40 µM. Approximately 20 µM of estradiol-17β was treated along with 5, 10 and 15 µM of allicin, separately, in the presence of metabolic activation. Similar treatments were given with 40 µM of estradiol-17β. Treatments along with allicin result in the reduction of CAs and SCEs, suggesting its anti-genotoxic activity in human lymphocytes in vitro against estradiol-17β-induced genotoxic damage.
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