Abstract
An antigen-specific factor capable of augmenting delayed-type hypersensitivity (DH) in the culture supernatants from immune spleen cells and erythrocyte antigen has been found. These culture supernatants also augmented an immediate hypersensitivity-like reaction which appeared in advance of the classical DH reaction. In this paper, the basic characteristics and cells producing the augmentation factor (IAF) involvd in immediate hypersensitivity-like reaction were investigated, (i) Maximum activity of IAF was detected in a supernatant from 24-hr culture of immune spleen cells and antigen, (ii) In vitro antigen stimulation was essentially required for the production or release of IAF. (iii) IAF showed antigen-specificity, (iv) IAF was produced or released by T cells. In addition to these facts, the DH-augmentation factor proved to be a T-cell product.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
