Antidiabetic Effect of Piper Sarmentosum: A Systematic Review

Abstract

Introduction: Diabetes mellitus (DM) is an endocrine, metabolic syndrome and has reached pandemic proportions worldwide. The multifactorial pathology results in the patient to including lifelong drug therapy for treatment. Alternative medicines such as traditional remedies using plant herbs to treat various diseases are common in most countries. Piper sarmentosum extracts have been as a traditional medicine to treat various diseases. The plant has abundant phytochemical properties such as alkaloids and flavonoids exhibiting pharmacological activities such as antidiabetic effects, antioxidant, anti-inflammatory, and anticancer. This paper aims to appraise the data into a comprehensive systematic review on the antidiabetic effect of P. sarmentosum and it’s potential in managing DM. Methods: This systematic review used the PRISMA method with searches in three electronic databases such as SCOPUS, PUBMED and WEB OF SCIENCE in November 2021. Six articles were included based on the inclusion criteria. Results: The results showed a hypoglycaemic effect in induced diabetic models. Piper sarmentosum extracts significantly reduces fasting blood glucose and reduces the risk of diabetes complications related to renal and cardiovascular system. In summary, a promising result regarding antidiabetic activity was found. Conclusion: This finding suggests that this plant has the potential to be used as an alternative therapy or pair along with other medications to treat DM.