Abstract
Alstonia boonei is a well-known plant of medicinal value but its effect on endogenous plasma antioxidant in diabetes remains unknown. Thus, need to investigate the effects of the methanolic extract of the plant on plasma bilirubin and uric acid level in alloxan induced diabetes rabbits. Twenty five rabbits divided into five groups of four rabbits each were used. There was a significant change in the levels of total bilirubin and uric acid in the plasma of treated groups as compared with both non diabetes and untreated diabetes group, while conjugated bilirubin level was relatively unchanged in the treated group. This work clearly indicates that methanolic extract of Alstonia boonei stem bark is effective in the management of diabetes as well as restoration of lost endogenous plasma antioxidants experienced in diabetes mellitus.
Highlights
Diabetes mellitus is a metabolic disease that is as old as mankind; it is a major endocrine disorder and a growing health problem globally (Pickup and Williams, 1997)
*Corresponding author Email: humphrey.osadolor@uniben.edu further scientific scrutiny on this plant, this study aims at investigating possible hypoglyceamic and the corresponding effects of the methanolic extracts of A.boonei on plasma uric acid and bilirubin levels of alloxan induced rabbits
It was observed that all the rabbits that were not induced with alloxan-monohydrate moved freely throughout the period of experimentation while, the diabetic rabbits both treated and untreated appeared sluggish and highly lethargic
Summary
Diabetes mellitus is a metabolic disease that is as old as mankind; it is a major endocrine disorder and a growing health problem globally (Pickup and Williams, 1997). Uric acid is the end product of purine metabolism, where purines by enzymatic hydrolytic deamination form xanthine and hypoxanthine compounds which are than oxidized to uric acid (White, et al, 2004) It is an important physiological antioxidant by providing a primary defence against oxidants based upon its capacity to scavenge singlet oxygen and its ability to inhibit lipid peroxidation (Bhargava, et al, 2015). The use of natural remedies for diabetes treatment is strengthened due to the belief that herbs can provide some benefits over allopathic medicine and allows users to feel that they have some control in their choice of medication Their general acceptability has been limited by lack of dose regimen and adequate data on their toxicity (Joshi and Kaul, 2004).
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