Abstract
IntroductionPithecellobium dulce (Roxb.) Benth (Mimosaceae) commonly known as Manila tamarind, has been traditionally used for the treatment of diabetes mellitus. The present study investigated the attenuating effects of methanolic extract of Pithecellobium dulce seeds (PDM) on hyperglycemia, oxidative stress and hyperlipidemia in streptozotocin (STZ) induced diabetic rats. MethodsDiabetes was induced by intraperitoneal administration of STZ (50mg/kg) in male Wistar rats. Diabetic rats were treated with oral doses of PDM (125, 250 and 500mg/kg) daily for 21 days at the end of the experiment blood was withdrawn to measure glycosylated haemoglobin (HbA1C), insulin, total protein and lipid profile. The glycogen content of liver was estimated. Antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase), reduced glutathione and lipid peroxides were determined in liver, kidney and pancreatic tissue. Histopathological examination of liver, kidney and pancreatic tissues of treatment groups was also carried out. ResultsOral administration of PDM (125, 250 and 500mg/kg) for 21 days caused a significant decrease in fasting blood glucose, HbA1C and significant increase in body weight, serum insulin, total protein, and liver glycogen levels in treated diabetic rats. PDM effectively normalized dyslipidemia associated with streptozotocin-induced diabetes. In liver, kidney and pancreas, the activity of antioxidant enzymes and content of reduced glutathione were found to be significantly enhanced, while levels of lipid peroxides were suppressed in treated diabetic rats. ConclusionThe findings of the present study indicate that PDM possessed significant antihyperglycemic, antihyperlipidemic and antioxidant potential which may prove beneficial in the treatment of diabetes and associated complications.
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