Abstract
Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The extract was screened for hypoglycemic activity in alloxan-induced diabetic rats (120 mg/kg, i.p.) at two dose levels, viz., 100 and 200 mg/kg. The ethanol extract at 200 mg/kg dose level exhibited significant (p<0.05) hypoglycemic activity and also correction of altered biochemical parameters viz., cholesterol and triglycerides (p<0.05).
Highlights
Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids
The ethanol extract was subjected to qualitative phytochemical investigation for the identification of the phytoconstituents viz., sterols, alkaloids, glycosides, saponins, tannins, carbohydrates and ßavonoids[3,4,5,6]
Similar antidiabetic activity was seen in the ethanol extract of leaves of C. phlomoidis
Summary
Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The leaves of C. phlomoidis were collected during December 2004 from Trichy, India. Groups III and IV received the ethanol extract, orally at a dose of 100 mg/kg and 200 mg/kg respectively. Those animals with fasting blood glucose level between 170-300 mg/dl at 72 h after alloxan administration were divided into four groups of six animals each.
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