Abstract
Introduction: Bridelia ferruginea is a plant known for its antidiabetic properties. However, few studies on leaf extracts have induced anti-hyperglycemic activity on normal mice subjected to carbohydrate overload. The current study was designed to assess the effect of the leaf extracts’ fraction on fructose-induced diabetic mice. Methods: The in vitro ferric-reducing antioxidant power (FRAP) assay were carried out and the condensed tannins quantified. The vanillin-HCl method was used to characterize the condensed tannins. The antidiabetic effect on fructose-induced diabetic mice was evaluated for 28 days using a fructose-enriched fat diet approach. Results: The fraction confirmed the antioxidant activity with a reducing power of 800 μg/mL comparable to ascorbic acid at 200 μg/mL. The condensed tannins were estimated at 79.6 ± 3.4 mg catechin equivalent per gram of sample. Significant decreases in blood sugar levels of 6.25% at the 7th day, 11.04% at the 14th day, 12.61% at the 21th day, and 11.35% at the 28th day were obtained in mice treated with the extract dose of 200 mg/kg of body weight, compared to the positive control group. The decreases of 37.11% of triglycerides and 40.16% of total cholesterol were also obtained. Conclusion: The investigated fraction showed notable antidiabetic activity and might be a good candidate in the treatment of diabetes.
Highlights
Bridelia ferruginea is a plant known for its antidiabetic properties
Animals under the same diet but treated with B. ferruginea extract at a dose of 200 mg/kg showed a reduction in blood glucose levels of 6.25% (P < 0.05) at the 7th day, 11.04% (P < 0.01) at the 14th day, 12.61% (P < 0.01) at the 21st day, and 11.35% (P < 0.01) at the 28th day, compared to the positive control
The area under the blood glucose curve showed a significant increase of 19.84% (P < 0.001) of the positive control group compared to the control group, while the area of the B. ferruginea 200 group showed significant reduction of 8.85% (P < 0.05%) compared to the positive control
Summary
Few studies on leaf extracts have induced anti-hyperglycemic activity on normal mice subjected to carbohydrate overload. The current study was designed to assess the effect of the leaf extracts’ fraction on fructose-induced diabetic mice. Results: The fraction confirmed the antioxidant activity with a reducing power of 800 μg/mL comparable to ascorbic acid at 200 μg/mL. Significant decreases in blood sugar levels of 6.25% at the 7th day, 11.04% at the 14th day, 12.61% at the 21th day, and 11.35% at the 28th day were obtained in mice treated with the extract dose of 200 mg/kg of body weight, compared to the positive control group. Diabetes is one of the main public health issues in the world today [1] It is a metabolic disorder characterized by chronic hyperglycemia resulting from relative insulin deficiency, insulin resistance, or both [2]. Several other factors are associated with diabetic pathologies and their complications, mostly oxidative stress and altered antioxidant levels [5], while fructose can cause oxidative stress [6]
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