Antidepressant Activity of Curcuma heyneana

Abstract

BACKGROUND: The resistance to depression therapy remains high, and therapy failure leads to suicide. Curcuma heyneana (C. heyneana) is a plant of Zingiberaceae. Conventionally, the rhizome has been used as an anxiolytic and sedative. However, the activity as antidepression has never been conducted. AIM: Therefore, this research was aimed to investigate the antidepressant activity of C. heyneana rhizome. METHODS: This research was conducted using male mice aged 2–3 months. Chronic mild stress for 14 days was used to induce depression, followed by administration of the extract at 50, 100, and 200 mg/kg for 10 days. Evaluation of antidepression was carried out using tail suspension test (TST), forced swim test (FST), open field test (OFT), and blood glucose and injury of gastric. Sertraline at the dose of 6.5 mg/kg was used as a positive control. RESULTS: The result revealed that stress induction for 14 days causes decreasing in locomotor activity and increased immobility. The extract administration at the doses of 100 and 200 mg/kg showed increased locomotor activity, which can be seen from the elevation of the central square and cross in the OFT (p < 0.05). The extract also decreased immobility in the tail suspension and FSTs (p < 0.05). Furthermore, the extract also prevents increases in blood glucose and gastric irritation. CONCLUSION: Extract of C. heyneana rhizome at the doses of 100 and 200 mg/kg has antidepressant activity by increasing locomotor activity, decreasing immobility time, and preventing elevation of blood glucose and gastric injury.