Abstract
AbstractAnti-Ku antibodies and clinical associationsAnti-Ku antibodies, targeting a heterodimer composed of two subunits of 70 and 80 kDa, are associated with various connective tissue diseases, including systemic sclerosis, inflammatory myopathy or systemic lupus erythematosus. In most of the cases, indirect immunofluorescence on HEp-2 cells displays a typical fluorescent pattern, but anti-Ku antibodies may be associated with other autoantibodies, making their identification more difficult. Many articles have focused on describing the clinical manifestations and biological associations in patients with anti-Ku antibodies. However, these autoantibodies do not appear in any connective tissue diseases diagnostic criteria. Recently, several publications suggested a real prognostic interest of these autoantibodies, especially during inflammatory myopathies, highlighting the need to better identify the latter.
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