Abstract
Rutin is the bioactive flavanoid isolated from the straw part of Triticum aestivum and possess various pharmacological applications. The aim of this study is to evaluate the chemopreventive potential of rutin in an experimental skin carcinogenesis mice model system. Skin tumor was induced by topical application of 7,12-dimethyl benz(a) anthracene (DMBA) and promoted by croton oil in Swiss albino mice. To assess the chemopreventive potential of rutin, it was orally administered at a concentration of (200 mg/kg and 400 mg/kg body weight) continued three times weekly for 16th weeks. The development of skin carcinogenesis was assessed by histopathological analysis. Reductions in tumor size and cumulative number of papillomas were seen due to rutin treatment. Average latent period was significantly increased as compared to carcinogen treated control. Rutin produced significant decrease in the activity of serum enzyme serum glutamate oxalate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and bilirubin when compared with the control. They significantly increased the levels of enzyme involved in oxidative stress glutathione (GSH), superoxide dismutase (SOD) and catalase. The elevated level of lipid peroxidase in the control group was significantly inhibited by rutin administration. The results from the present study suggest the chemopreventive effect of rutin in DMBA and croton oil induced skin carcinogenesis in swiss albino mice and one of the probable reasons would be its antioxidant potential.
Highlights
Triticum aestivum Linn. commonly known as wheat grass belongs to the Gramineae and is being used in many native drug preparations
The results from the present study suggest the chemopreventive effect of rutin in dimethyl benz(a) anthracene (DMBA) and croton oil induced skin carcinogenesis in swiss albino mice and one of the probable reasons would be its antioxidant potential
In the present study attempts have been made to understand the chemopreventive potential of rutin isolated from Triticum aestivum in DMBA croton oil induced skin carcinogenesis mice model system
Summary
Triticum aestivum Linn. commonly known as wheat grass belongs to the Gramineae and is being used in many native drug preparations. Quercitin-3-rutinoside and sophorin extensively found in many plants, including Triticum aestivum This flavanoid has a broad range of biological activities antimicrobial [7], anti-inflammatory [8,9], antioxidant [10], neuroprotective [11], antiviral [12], and antiulcerogenic [13]. Rutin attaches to the iron ion, preventing it from binding to hydrogen peroxide which could otherwise create a highly reactive free radical that may damage cell. It is antioxidant and plays a role in preventing some cancer [15]. In the present study attempts have been made to understand the chemopreventive potential of rutin isolated from Triticum aestivum in DMBA croton oil induced skin carcinogenesis mice model system
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