Abstract
The present work resulted in isolation and purification of two potential anticancer compounds from Chaetomium globosum isolated from Egyptian soil. The two compounds were tested against Michigan Cancer Foundation-7(MCF-7) breast cancer cell line and Hepatocellular carcinoma, Human (HEPG-2) a human liver carcinoma cell line and showed inhibition effect on the proliferation of two cell lines. The structures of the two pure compounds were elucidated by HNMR and Mass spectroscopy as methyl 9-dihydro-8-trihydroxy-9-oxo-Hxanthene- 1-carboxylate as a member of xanthones and (E)-methyl 2-hydroxy-6, 6-dimethyl hept-3-enoate.
Highlights
Chaetomium Kunze is a large genus of the Chaetomiaceae Winter Sordariales Chad
One of these secondary metabolites is xanthones, phomoxanthones A 99 and B 100, two novel xanthones dimmers both exhibited cytotoxic activity against KB cells, BC-1 cells and non-malignant cells [4,5] Isolate four new metabolites, chaetomugilins P–R and 11-epi-chaetomugilin I from C. globosum which significantly inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines
A novel cytotoxic chlorinated azaphilone derivative named chaetomugilin D, with chaetomugilin A, chaetoglobosins A and C, isolated by a bioassay-guided fractionation from the EtOAc extract of C. globosum [7,8] Isolate a new metabolite named chaetoglobosin X, together with three known compounds erogosterol, ergosterol 5α, 8-peroside and 2methyl-3-hydroxy indole from C. globosum isolated from medicinal plant Curcuma wenyujin
Summary
Chaetomium Kunze is a large genus of the Chaetomiaceae Winter Sordariales Chad. Ex D. One of these secondary metabolites is xanthones, phomoxanthones A 99 and B 100, two novel xanthones dimmers both exhibited cytotoxic activity against KB cells, BC-1 cells and non-malignant cells [4,5] Isolate four new metabolites, chaetomugilins P–R and 11-epi-chaetomugilin I from C. globosum which significantly inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines.
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