Abstract
Aim of this study was to synthesize the safe and stable zinc oxide nanoparticles (ZnONPs) from the leaves of Artocarpus heterophyllus. The alter in the color of the leaf extract dark brown upon addition of zinc nitrate Zn(NO3) confirms the formation of Zinc Oxide nanoparticles (ZnONPs). UV-VIS spectrophotometric analysis showed lambda max at 235 nm while Fourier transform infra-red (FTIR) spectroscopy showed various amines and amides are involved in the stabilization of ZnONPs. Energy dispersive X –rays (EDX) confirms the presence of zinc. Transmission electron microscopy (TEM) analysis revealed particle size ranges from 12 to 24 nm. These observed characteristic of nanoparticles are extremely useful in anticancer activities against HCT-116 colon cancer cell line. These ZnONPs showed IC50 value at 20μg/ml while on normal Vero cell line showed less effective by MTT assay. Furthermore, these nanoparticles were evaluated for apoptotic activity by acridine orange/ethidium bromide (AO/EB) double staining method showed the membrane blebbing and chromatin condensation.
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