Abstract
Antibody to homogeneous terminal deoxynucleotidyl transferase (EC 2.7.7.31, nucleoside triphosphate: DNA deoxynucleotidylexotransferase) from calf thymus gland has been prepared using crosslinked antigen derivatives in rabbits. The antisera produced precipitate and neutralize homologous antigen, and crossreact with human, chicken, mouse, and rat terminal transferase. Antiserum to pure terminal transferase provides greatly expanded analytical capabilities for further studies on terminal transferase biology and structure.
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