Abstract
Relevance. Microbiological monitoring in medical organizations is an essential part of ensuring epidemiological safety in the provision of medical care. The study of the sensitivity of pathogens to antibacterial drugs allows us to reasonably approach the prescription of empirical therapy and form a form of antibacterial agents for medical organization. The purpose of the work was to study the species composition of pathogens of generalized purulent septic infections (GPSI) in a children's multidisciplinary hospital and determine their resistance to antibacterial drugs. Materials and methods. Analysis of microbiological analysis data of material taken from patients with GPSI treated in children's multidisciplinary hospital in the period 2013-2018 was carried out. A total of 572 cultures were studied. Results. It was found that the largest specific gravity in the structure of GPSI was occupied by gram-negative microorganisms, the proportion of which significantly decreased from 73.0% in 2013 to 48.1% in 2018. Gram-positive microorganisms were found in 27.0 ± 8.1% cases, while a significant increase in the proportion of fungi from 5.4 to 30.7% was observed. The antibiotic resistance of the main pathogens has been studied. Among non-fermenting gram-negative bacteria, the highest (p < 0.05) multi-resistivity indicator was found in Acinetobacter baumannii (50.0 ± 6.8%). Enterococcus, having high natural resistance to a number of antibiotic groups, leave the possibility of effective action of the preparation of the group of glycopeptides (vancomycin) against Enterococcus faecium. Conclusions. High pathogens to applied antibacterial preparations is shown. The obtained data make it possible to form an up-to-date form of antimicrobial drugs for use in children's hospitals, to develop measures that inhibit the development of resistance in pathogens of purulent-inflammatory diseases.
Highlights
It was found that the largest specific gravity in the structure of generalized purulent septic infections (GPSI) was occupied by gram-negative microorganisms, the proportion of which significantly decreased from 73.0% in 2013 to 48.1% in 2018
Sci. (Med.), associate professor of Epidemiology and Microbiology in Irkutsk State Medical Academy of Continuing Education, researcher of the Laboratory of the Epidemiologically and Socially Significant Infections of Scientific Сentre for Family Health and Human Reproduction Problems, 16 Timiryazev St., Irkutsk, 664003, Russia 8(3952) 33-34-25, chemezova_nataly@mail.ru. ©Noskova OA et al Практические аспекты эпидемиологии и вакцинопрофилактики Practical Aspects of Epidemiology and Vaccine Prevention indicator was found in Acinetobacter baumannii (50.0 ± 6.8%)
Structure of microflora isolated from patients with generalized purulent septic infections
Summary
Целью работы явилось изучение видового состава возбудителей генерализованных гнойно-септических инфекций (ГГСИ) в детском многопрофильном стационаре и определение их устойчивости к антибактериальным препаратам. Антибиотикорезистентность возбудителей генерализованных гнойно-септических инфекций у детей. The purpose of the work was to study the species composition of pathogens of generalized purulent septic infections (GPSI) in a children's multidisciplinary hospital and determine their resistance to antibacterial drugs. Результаты исследования Исследования показали, что за изучаемый период (2013–2018 гг.) этиологическими факторами тяжелой гнойно-септической патологии у пациентов крупного многопрофильного детского стационара выступали 19 видов микроорганизмов, среди которых наибольшее эпидемиологическое значение имели Acinetobacter baumannii (19,9 ± 2,0 %), Candida albicans (13,6 ± 1,7 %), K. pneumoniae (11,5 ± 1,6%), P. aeruginosa (10,3 ± 1,5%) Enterococcus faecium (10,1 ± 1,5%) Structure of microflora isolated from patients with generalized purulent septic infections
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
