Abstract
Human immunodeficiency virus (HIV) infection is a serious problem throughout the world and especially in developing countries. This study was conducted to define the bacterial aetiologies of enteric disorders and their association with CD4+ T-lymphocyte cell count and serum hs-CRP in HIV-seropositive patients coming for consultation at the AD-Lucem Banka Hospital. Stool samples from one-hundred HIV-positive patients with enteric disorders and forty HIV negative patients with enteric disorders were examined for the presence of bacteria by different diagnostic techniques. CD4+ T-lymphocyte count and serum hs-CRP of HIV-positive and HIV-negative patients were examined, respectively, by flux cytometry and the ELISA solid-phase direct sandwich method. Among all the participants, 39 (26.35%) were males and 109 (73.65%) were females. HIV-seropositive mean age (43.79 years) was significantly higher compared to HIV-seronegative (27.13 years) patients (p < 0.000). The average values of CD4+ T-cell count (p < 0.0001), lymphocytes (p=0.0258), monocytes (p=0.0317), and total WBC count (p=0.0277) were significantly higher in HIV− patients compared to HIV+ patients. Salmonella sp., Escherichia coli, and Klebsiella pneumoniae were more isolated in HIV+ patients 5 (83.33), 18 (75.00), and 37 (71.15) compared to HIV− patients 1 (16.67), 6 (25.00), and 15 (28.85), respectively. Majority of isolates were susceptible to IPM, NOR, and CIP. Klebsiella pneumoniae, the most prevalent isolate, showed resistance to AMC (45.95) in HIV+ patients, whereas in HIV− patients, Enterobacter aerogenes and Shigella sp. showed resistance to AMC (80.00% and 85.71%, respectively) and to CFM (80.00% and 57.14%, respectively). Enterobacter aerogenes (40.00%) and Shigella sp. (14.29) isolates showed multidrug resistance in HIV− patients, whereas Escherichia coli (5.56%) and Klebsiella pneumoniae (2.70%) showed multidrug resistance in HIV+ patients. Understanding the burden of bacteria disease in HIV patients as shown in the present study is important for planning effective control programs for the overall reduction of bacteria diseases in HIV-infected patients.
Highlights
To better understand the bacterial aetiologies of enteric disorders in people living with Human immunodeficiency virus (HIV)/AIDS in Bafang-Cameroon, this study was conducted to determine the association between CD4+ T-lymphocyte cell count, serum hs-C-reactive protein (CRP) levels, and intestinal bacteria colonisation and their resistance in HIV-seropositive patients on consultation at the AD-Lucem Banka Hospital
It appears that the average values of CD4+ T-cell count (p < 0.0001), lymphocytes (p 0.0258), monocytes (p 0.0317), and total White Blood Cell (WBC) count (p 0.0277) were significantly higher in HIV− patients compared to HIV+ patients
Is result is similar to that of Marbou and Kuete’s statistics with an estimated adult (31–50 age group) HIV prevalence of 55.88% in 2017 [6]. e female preponderance observed in the present study might have been due to the fact that females are more biologically vulnerable to HIV infections [11]. e mean age of HIV positive patients was 43.79 ± 15.24 years. e higher mean age of clinical presentation of HIV-positive patients may be because in our country, HIV infection is suspected when some clinical signs and symptoms start appearing or when illness is quite advanced
Summary
More than 90% of microbial infections occur in less favoured areas of the planet every year [1]. ey are the second leading cause of death in the world, with more than 17 million deaths each year, nearly 90% of them in developing countries [2]. Ey are the second leading cause of death in the world, with more than 17 million deaths each year, nearly 90% of them in developing countries [2]. Most of these infections are caused by bacteria that cause many diseases and, as a result, high rates of death. To better understand the bacterial aetiologies of enteric disorders in people living with HIV/AIDS in Bafang-Cameroon, this study was conducted to determine the association between CD4+ T-lymphocyte cell count, serum hs-CRP levels, and intestinal bacteria colonisation and their resistance in HIV-seropositive patients on consultation at the AD-Lucem Banka Hospital
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Schedule a callMore From: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
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