Abstract
Endocrine-disrupting chemicals (EDCs) possess a significant risk to humans and have a negative influence on human health. Some EDCs can act like “hormone mimics,” some can block natural hormones from their activity, while some can enhance or reduce the blood harmone level, thus interfering with the body’s normal metabolism. Obesity, diabetes, hyperlipidemia, and metabolic syndrome are all potentially sensitive to EDCs. Another major concern currently is antibiotic resistance which is rising to an alarming level throughout the world. New mechanisms of antibiotic resistance are emerging and spreading out worldwide, threatening the clinical practice in the treatment of common infectious diseases. Antibiotic resistance can occur due to the misuse or overuse of antibiotics as well as the insufficiency of new drug development. Some pathogens are also becoming resistant in the same way with the use of antibiotics to treat infections associated with EDCs-induced metabolic disorders. This manuscript highlights the mechanism and acquisition of antibiotic resistance and their effect on metabolic disorders such as diabetes, obesity, and atherosclerosis which can ultimately result in cardiovascular diseases.
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