Abstract
On page 1351, Li-li Li and Hao Wang report lysozyme-coated mesoporous silica nanoparticles as anti-bacterial agents that exhibit efficient antibacterial activity both in vitro and in vivo with low cytotoxicity and negligible hemolytic side effect. The lysozyme corona provides multivalent interaction between nanoparticles and bacterial walls, promoting hydrolysis of peptidoglycans and increased membrane-perturbation abilities. The survival bacteria in colon are three orders of magnitude lower than that in the untreated group.
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