Abstract
Methicillin resistant Staphylococcus aureus (MRSA) are resistant to all I²-lactam antibiotics and patients suffering from MRSA infections may lead to higher mortality rate and prolonged antibiotic therapy. Use of metallic nanoparticles treating infections caused by antibiotic resistant strains is a new paradigm. Sesbania grandiflora and Solanaum xanthocarpum were used for the synthesis of silver nanoparticles (Ag-NPs). A total of 55 strains were isolated from hospital environments in which 12 were identified as MRSA. Antibacterial activity of the green synthesized Ag-NPs against MRSA was assessed by determining the minimal inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and by measuring the dynamic growth curve of the bacteria. Further, toxicity assay of synthesized Ag-NPs on HeLa cell lines were performed. The MIC and MBC values of S.
Highlights
Staphylococcus aureus cause complications ranging from minor to life-threatening infections in wide range of host species
The objective of this study is to determine the effects of green synthesized Ag-NPs using Sesbania grandiflora and Solanum xanthocarpum extracts against Methicillin resistant Staphylococcus aureus (MRSA) isolated from hospital environments
MRSA has led to serious concern in human medicine [30] and patients suffering from MRSA infections may need antibiotics that are more potent and less toxic
Summary
Staphylococcus aureus cause complications ranging from minor to life-threatening infections in wide range of host species. Methicillin resistant Staphylococcus aureus (MRSA) is resistant to methicillin, oxacillin, amoxicillin and penicillin [1]. MRSA are resistant to all β-lactam antibiotics and some strains evolved resistance to mulitiple antibiotics. Methicillin resistant Staphylococcal infections lead to a higher mortality rate and prolonged antibiotic therapy as compared with methicillin sensitive Staphylococcal infection [2,3]. It is important to develop alternative and more effective therapeutic strategies to treat multidrug resistant pathogens. Nanoparticles are being used for combating microbial resistance and have advantages over traditional antibiotics [4]. The antimicrobial activity mechanism by antibiotics is quite different from the mechanisms by which nanoparticles inhibit microbial growth. Nanoparticles have the potential to serve as an alternative to antibiotics [5]
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