Abstract
Objective: The present study aim to investigate the anti-psychotic potential of pyrus communis in the rodents.Methods: The fresh juice of pyrus communis (Pear) was administered orally to rodents for 21 d and the anti-psychotic activity was assessed by in vitro methods viz ketamine induced stereotypic behaviour, pole climbing avoidance in rats and swim induced grooming behaviour experimental models. The biochemical estimation was done on 21 d.Results: The different concentrations of fresh pyrus communis juice was assayed. When pyrus communis juice (PCJ) was administered chronically for 21 d remarkably decreased ketamine induced falling, head-bobbing, weaving and turning counts. Administration of Pear juice significantly delayed the latency time taken by the animals to climb the pole in Cook’s pole climb apparatus. In swim induced grooming behaviour model, Pear juice significantly reduced swim induced grooming behaviour. Moreover, Pear juice significantly decreased the brain dopamine levels and inhibited acetyl cholinesterase activity. In the present study, Pear juice significantly enhanced reduced glutathione levels in the brains of mice, thereby reflecting enhanced scavenging of free radicals and in turn preventing occurrence of psychotic attack.Conclusion: The present study revealed that pyrus communis juice possessed significant anti-psychotic activity.
Highlights
Nature has blessed us with a wonderful flora and fauna, which has made our life lovely
Oxidative stress is the condition arising from an imbalance between toxic reactive oxygen species and antioxidant systems [13]
In the condition of schizophrenia, the balance between the ROS and the antioxidant system is disturbed [14]. Exogenous antioxidants such as those present in Pear juice protect cells from the damage caused by ROS, as they interact with free radicals and prevent some of the neuronal damage
Summary
Nature has blessed us with a wonderful flora and fauna, which has made our life lovely One of these wonders is Pear fruit. Each part of Pear tree has high nutritional value and possesses multiple medicinal properties such as anti-inflammatory, sedative, antipyretic, antioxidant, hypolipidemic, hypoglycaemic, anti-aging, analgesic, spasmolytic, anti-tussive, anti-diarrheal, wound healing, anti-microbial and hepatoprotective [1]. It holds 2nd rank after apple in nutrition amongst cultivated fruits. Pear possesses promising neuroprotective properties thereby preventing the development of neurodegenerative diseases such as Parkinsonism, Huntington’s disease and Alzheimer’s disease [1]. Regular consumption of Pear lowers the risk of age-related macular degeneration, which is the main cause of vision loss in older adults
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