Abstract

Metals contribute important roles in biological system. It is recognized that metals are highly linked in cellular and subcellular functions. With the application of novel and experienced tools to study biological and biochemical systems the true role of inorganic salts in biological systems can be studied. Schiff base metal complexes show a broad range of biological activity. The activity of Schiff base ligand is usually increased by complexation with the metal ion. The copper complexes of Schiff bases have striking properties such as antibacterial, antifungal, antiviral, anti-inflammatory, anti-tumor and cytotoxic activities, plant development controller, enzymatic activity and applications in pharmaceutical fields. The divalent cations Zn2+, Ca2+ and Mg2+ prevent cytotoxicity and in vivo antagonize Cd- induced carcinogenesis. Lack of body iron is common in cancer patients and it is associated with complications in surgery and in animal experiments. The transport of iron and other metal ions by the blood plasma is achieved through the formation of protein complexes. Copper is placed as a vital metalloelement and is primarily connected with copper-dependent cellular enzymes. Metals are also used as inorganic drugs for many diseases. In this review our main focused on research undertaken for biological activity study of Cu(II) metal complexes containing Schiff bases over the past few decades.

Highlights

  • Schiff bases containing imine or azomethine (-RC=N-) are condensation products of primary amines and carbonyl compounds

  • L corresponds to the Schiff base ligand, which prepared by condensation of cefotaxime with salicylaldehyde were synthesized by Aurora Reiss et al All the synthesized complexes and Schiff base were tested for in vitro antibacterial activity against some pathogenic bacterial strains, namely, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus [28]

  • The antibacterial activity of synthesized Schiff base and its metal complexes have been studied by the agar well diffusion method using dimethylformamide (DMF) as a solvent against various bacterial pathogenic strains such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Enterococcus [39]

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Summary

Introduction

Schiff bases containing imine or azomethine (-RC=N-) are condensation products of primary amines and carbonyl compounds. Schiff-bases may function as mono-, di-, tri-, or tetradentate ligands depending on the number of coordinating atoms present in the molecule and can construct usually five or six membered chelate rings upon reaction with a metal ion [2] They are well known for their biological applications as antibacterial, antifungal, anticancer, antiviral, antiparasitic, and antitumor agents [3,4,5]. The complexes of copper (II) ion containing Schiff bases possess remarkable properties as catalysts in various biological systems, polymers, dyes, antimicrobial activities, antifungal activities, antiviral activities, anti-inflammable activities, antiradical activities, plant growth regulator, enzymatic activity, insecticides, antitumor and cytotoxic activities. Different biological activity of Cu(II) containing Schiff base metal complexes have been mentioned in the later descriptions

Antibacterial Activity
Antifungal Activity
DNA Interaction Studies
Conclusion
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