Abstract
BackgroundRadix notoginseng is used in Chinese medicine to improve blood circulation and clotting; however, the pharmacological activities of other parts of Panax notoginseng have yet to be explored. The present study reports the anti-oxidative effects of various parts of Panax notoginseng.MethodsVarious parts of Panax notoginseng, including the biennial flower, stem-leaf, root-rhizome, fiber root and sideslip, were used to prepare extracts and analyzed for their anti-oxidation effects, namely suppressing xanthine oxidase activity, H2O2-induced cytotoxicity and H2O2-induced ROS formation.ResultsAmong various parts of the herb (biennial flower, stem-leaf, root-rhizome, fiber root and sideslip), the water extract of the biennial flower showed the strongest effects in (i) inhibiting the enzymatic activity of xanthine oxidase and (ii) protecting neuronal PC12 cells against H2O2-induced cytotoxicity. Only the water extracts demonstrated such anti-oxidative effects while the ethanol extracts did not exert significant effects in suppressing xanthine oxidase and H2O2-induced neuronal cytotoxicity.ConclusionsThe present study demonstrates the biennial flower of Panax notoginseng to have neuroprotection effect on cultured neurons and the underlying protection mechanism may involve anti-oxidation.
Highlights
Radix notoginseng is used in Chinese medicine to improve blood circulation and clotting; the pharmacological activities of other parts of Panax notoginseng have yet to be explored
In the presence of vitamin C at various concentrations (0, 17.6, 35.2, 52.8 and 88 μg/ml), xanthine oxidase effects were suppressed in a dose-dependent manner, with maximum inhibition of 80% as compared with the control (Figure 1A), validating this anti-oxidation assay
Different parts of Panax notoginseng including the biennial flower, stem-leaf, root-rhizome, fiber root and sideslip were separated from the whole plant (Figure 2) and subjected to water extraction
Summary
Radix notoginseng is used in Chinese medicine to improve blood circulation and clotting; the pharmacological activities of other parts of Panax notoginseng have yet to be explored. Panax notoginseng is beneficial for coronary heart disease, cerebral vascular disease as well as learning and memory improvement [3,4,5,6,7]. These therapeutic effects are attributed to its active ingredients, namely saponins [8,9], flavonoids [10] and polysaccharides [11,12]. The present study examines the antioxidation effects of other parts of Panax notoginseng
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