Abstract
This study evaluated the anti-obesity effects of Artemisia capillaris extracts in high-fat diet (HFD)-induced obese rats. After six weeks feeding with HFD, Wistar male rats (12-weeks-old) were divided into three groups: HFD-control group and HFD mixed with 0.4% and 0.8% Artemisia capillaris extracts treated groups. After seven weeks of treatments, the body weight gain of the 0.4% and 0.8% A. capillaris extracts treated groups were significantly less than that of the HFD-control group by 11.8% and 15.4%, respectively. Also, A. capillaris extracts treated groups showed significantly lower serum TG, TC and LDL-c levels in a dose-related manner, while causing the reverse effect in serum HDL-c, and exhibited a hepatoprotective effects in vivo, indicated by reduced hepatic lipid contents, and serum ALT and AST levels. These results show that A. capillaris extracts may prevent body weight increases and improve dyslipidemia in HFD-induced obese rats by enhancing their lipid metabolism.
Highlights
Obesity is often associated with dyslipidemia, cardiovascular risks, hypertension and type 2 diabetes mellitus and has recognized as one of the most serious public health problems [1]
The scoparone obtained at 15 min has identical retention time and monitored at 274 nm as a main active compound of A. capillaris extracts
The weight of epididymal adipose tissue in A. capillaris extracts treated group was significantly decreased compared to the high-fat diet (HFD)-control group. These results suggest that A. capillaris extracts may prevent the accumulation of white adipose tissue (WAT) in HFD-induced obese rats
Summary
Obesity is often associated with dyslipidemia, cardiovascular risks, hypertension and type 2 diabetes mellitus and has recognized as one of the most serious public health problems [1]. Many studies have been conducted to find and develop the new anti-obesity drugs or dietary supplements through the use of medicinal plants that could minimize the side effects [3,4]. A. capillaris and has potent hepatoprotective [15], immunosuppressive [16], vascular relaxant [17] and anti-diabetic effects [18]. These reports led us to hypothesize that high content of scoparone in. A. capillaris extracts could serve as a potent therapeutic agent for the obesity. Their efficacy needs to be scientifically evaluated in vivo experiments. A. capillaris extracts was further investigated by high-fat diet (HFD)-induced obese rats
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