Anti-mullerian hormone, follicular phase follicle stimulating hormone and antral follicular count as predictors of ovarian response in assisted reproductive technique cycles

Abstract

Aim: Aim of the study is to correlate Serum Anti-Mullerian Hormone (AMH) levels, Follicular phase Follicle stimulating Hormone (FSH) levels and Antral Follicular Count (AFC) with ovarian response in ART (Assisted reproductive Techniques) cycles. Materials and Methods: Seventy patients undergoing ART cycles for various factors were included in the study. They were divided in two groups according to number of oocytes retrieved at ovum pick up procedures. Four or less number of oocytes were considered as poor response (n=32) and more than four oocytes were considered as good response (n=38). Two groups were compared for their Age, Duration of Marriage, Follicular phase FSH, AMH levels, pregnancy rates and cycle cancellation rate. Results: We found that the age and duration of infertility were not statistically different in two groups. AMH value in poor responders was 1.20ng/ml and in good responders it was 3.38 ng/ml with statistically significant difference (p< 0.05). The difference in FSH levels (7.36 Vs5.99) and AFC (5 Vs 12) was statistically significant. Pregnancy rate in poor responder group was very low as compared to good responders (6.25 Vs 18.42). In good responders none of the cycle got cancelled whereas in poor responders group five cycles got cancelled (15.63%) either due to failure to retrieve mature oocytes or failed fertilization due to poor quality of oocytes. Conclusion: It appears that AMH serum Levels baseline FSH and antral follicular count are associated with ovarian response in ART cycles and can be served as markers for ovarian reserve.