Abstract
Background: The aim of present study is to evaluate the anti-inflmmatory activity of Chlorella vulgaris in acute and chronic experimental inflammatory model. Plant extract was analyzed for photochemical screening of different phytoconstituents. Methods: Paw edema was induced with 1.5% carrageenan to all the groups except normal. Diclofenac was used as a standard drug and Chlorella vulgaris at 50, 100, 200 mg/kg dose was used for study. Carrageenan was administered in the paw. Paw thickness was measured at 0, 1, 2 and 4 hr. Inflammatory cytokines and oxidative stress were measured in paw homogenate. Chronic inflammatory activity was screened by using cotton pellet induced granuloma. Results: In result, paw thickness was increased from 1 hr to 4 hr and Chlorella vulgaris treated group shows decrease in paw thickness. SOD and GSH content was decreased and MDA level increased in carrageenan injected group, however treatment groups shows reverse effects also we found that increase in cytokine level in carrageenan group and decrease in treatment group. In, egg albumin model paw volume was decreased in rats treated with Chlorella vulgaris. In chronic model CV treated group also showed dose dependent activity. Conclusion: From this study we conclude that Chlorella vulgaris has antiinflammatory activity.
Highlights
Inflammation reflects a local reaction to injury from living tissues
Throughout this study we conducted photochemical screening of paw inflammation caused by Chlorella vulgaris and carrageenan by measuring paw length, oxidative stress and cytokine level
We observed that the carrageenan injected community showed an improvement in the volume of the paw and a single dose treatment with Xanthium Indicum based on Carrageenan-induced paw inflammation
Summary
Inflammation reflects a local reaction to injury from living tissues. This is a body defensive reflex to remove the injurious force.[1]. The diverse occurrences and facilitators associated in the hypersensitivity reaction may cause other responses or exacerbate these Immune cytokine such as tumer necrosis factor, IL-6 and IL-1β are increased in state of inflammation.[3] Chlorella vulgaris Beijerinck is a single-celled fresh-water algae super-food and is thought to be one of the planet’s earliest life-forms. Marine natural product search has yielded a considerable number of drug candidates.[8] The chemical compounds responsible for the antibacterial activity in algae have been variously identified as bromophenols, carbonyls, halogenated aliphatic compounds, terpenes, isoprenylated and brominated hydroquinones, as well as phlobatannins.[9] Throughout this study we conducted photochemical screening of paw inflammation caused by Chlorella vulgaris and carrageenan by measuring paw length, oxidative stress and cytokine level.
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