Abstract
Aims: An experiment was conducted to evaluate the anti-inflammatory effects of ethanolic bark extract of Plumeria obtusa. Material and method: Anti-inflammatory activity was evaluated by using two different animal models namely cotton pellet method and carrageenan induce paw edema in male Wistar rats at a dose of 100,200 and 400 mg/kg respectively. Results: Phytochemical examination of the extract exposed the existence of alkaloids, flavonoids, tannins and terpenoids. The ethanolic extract elicited highly significant (p<0.001) inflammatory activity in a dose dependent manner on cotton pellet method and carrageenan induce paw edema method. This was noticed by prominently decrease of paw volume in carrageenan induce paw edema and marked increase in % inhibition of cotton pellet Granuloma pouch at the dose of 100,200 and 400 mg/kg respectively. Conclusion: The present investigations showed that the ethanolic extract Plumeria obtusa stem bark has potential anti-inflammatory activity when screened on carrageenan-induced paw edema and cotton pellet Granuloma pouch models in rats.
Highlights
Primary vascular tissue has a complex biological response to harmful stimuli, such as pathogens, damaged cells, or an irritant is known as inflammation
The 1 kg of dried Stem bark of Plumeria obtusa was cleaned by removing contaminated materials, and were pulverized by an electric blender to give 600 gm of coarsely powder and stored in the airtight container
The coarse powder of stem bark of Plumeria obtusa was extracted with ethanol in Soxhlet extractor
Summary
Primary vascular tissue has a complex biological response to harmful stimuli, such as pathogens, damaged cells, or an irritant is known as inflammation. It is a process by which the body’s chemicals and white blood cells protect us from infection and foreign substances such as viruses and bacteria. Inflammation is an vital physiological reaction which happens in reaction to an extensive variety of Injurious agents (e.g. bacterial infection or physical trauma) trying to perform the dual function of promoting tissue repair
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