Abstract
To prepare the ethanolic extract of fresh fruits of Morus Rubra through maceration method and study the antihyperlipidemic effects of the extracts in Triton X-100 induced hyperlipidemia rats. The fresh fruits of Morus Rubra were purchased from local Chinese medicine store. The air-dried fresh fruits of Morus Rubra were extracted with absolute ethanol (99-100%) through maceration method for 8 days. Hyperlipidemia was induced in male Sprague-Dawley rats by 10% Triton X-100 (100mg/kg, i.p) injection. Hyperlipidemia rats were treated with simvastatin (20mg/kg, p.o) or fresh fruits of Morus Rubra extract (100, 200 and 400 mg/kg, p.o) for 7 days. The blood samples were collected before and after treatment of simvastatin and extract to access antihyperlipidemic effect of an ethanolic extract of fresh fruits of Morus Rubra. The mass of the rats also weighted at regular interval which is at day 1, 3 and 7. At the end of the experiment, serum lipid profile was analyzed for all the experimental animals and compared with hyperlipidemic control. The ethanolic extract of fresh fruits of Morus Rubra at 100, 200 and 400 mg/kg has showed significant antihyperlipidemic activity. The experiment rats exhibited a significant change in lipid profile as compare to hyperlipidemia group. The ethanolic extract of the fresh fruits of Morus Rubra showed significant antihyperlipidemic activity against Triton X-100 induced hyperlipidemia rats
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