Abstract
The <i>ipso</i>-substitution of one (or two) hydroxy groups of phloroglucinol with arene nucleophiles (e.g., <i>o</i>-xylene, tetralin, biphenyl) can be achieved easily under Friedel–Crafts-type conditions with or without the use of organic solvents affording a variety of 3,5-dihydroxybiphenyls (57–89% yields). The new method has significant practical advantages compared to classical biaryl-coupling routes.
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