Abstract
BackgroundA high-sugar or/and high-fat diets is a major risk factors for obesity. However, increased fruit and vegetable intake has been recently linked to obesity prevention. The aim of the present study was to investigate the preventive effects of pomegranate leaves (PL), juice (PJ) and peel (PP) extracts, on insulin resistance and oxidative stress in high fat and high fructose diet-induced obese rats.MethodsObesity in rats was induced by consumption of diet high in saturated fat and fructose (HFD) for a long period (12 weeks).ResultsCompared to the control group (CG) fed chow died, the high fat and high fructose diet (HFD) group showed a significant increase in the fasted plasma levels of glucose (29.8%), insulin (45%), amylase (70%) and lipase (54%). Moreover, HFD feeding has increased lipid peroxidation and protein carbonylation and decreased antioxidant enzymes levels. However, PL, PJ and PP treatment markedly prevents glucose intolerance, insulin resistance and oxidative stress and decrease amylase and lipase levels.ConclusionThese findings highlight that a long-term intake of pomegranate extracts might be a potential alternative strategy for the prevention of a HFD induced insulin resistance and oxidative stress.
Highlights
A high-sugar or/and high-fat diets is a major risk factors for obesity
The three remaining groups were fed with high in saturated fat and fructose (HFD) and received daily per gavage one of three pomegranate extracts at a dose of 250 mg/kg of Body Weight (BW), pomegranate juice (Group HFD+ PJ) pomegranate peel and pomegranate leaves
PJ was more concentrated in Unsaturated fatty acids (UFA) and pomegranate leaves (PL) presented the highest percentage of SFA
Summary
A high-sugar or/and high-fat diets is a major risk factors for obesity. The aim of the present study was to investigate the preventive effects of pomegranate leaves (PL), juice (PJ) and peel (PP) extracts, on insulin resistance and oxidative stress in high fat and high fructose diet-induced obese rats. Obesity is a condition marked by an expansion in subcutaneous and /or visceral adipose tissue. This fat accumulation results in an increase in a chronic systemic inflammation. This long term low grade inflammation induces a dysregulation in glucose and fatty acid metabolism, leading to insulin resistance [4, 5].
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