Abstract
The present study was designed to investigate the potential of raw-extract of Centella asiatica (RECA) in suppressing acetylcholinesterase (AChE), inflammations and oxidative stress via induction of lipopolysaccharide (LPS) on animal model of Sprague Dawley rats. Centella asiatica is a plant that has been used as a traditional herbal remedy for the management of several diseases, including memory improvement, treatment of mental fatigue and wound healing. Pre-treatment with RECA in vitro significantly reduced the AChE activity in a concentration-dependent manner with IC50 value of 57.47 ± 13.55 µg/ml. Interestingly, this result was parallel with in vivo studies. Moreover, the level of pro-inflammatory cytokines and oxidative stress were significantly reduced by RECA in dose-dependent manner. Overall, our findings clearly dictate the potential of RECA as AChE inhibitor as well anti-inflammatory and anti-oxidant agents.
Highlights
Alzheimers disease (AD) is a progressive, debilitating and heterogeneous neurological disorder, which is characterized clinically by memory loss, impaired cognitive functions and inappropriate behaviour that serious enough to impose severe strains on the social welfare systems. The etiopathogenesis of this disease is multifactorial and recent evidence demonstrates that the deficits in central cholinergic neurotransmission in the brain, inflammatory injury and induction of oxidative stress interrelated on progression of AD [1], [2]
Various uses are claimed for the plant, which has been used for centuries in Ayurvedic and Chinese traditional medicines for memory improvement, treatment of mental fatigue, wound healing, asthma and toxic fever [20]–[22]
Similar results were obtained by Xu et al when tested with another terpenoid of C.asiatica, madecassoside [48], [49]. These findings suggest that higher anti-inflammatory and antioxidant activities exerted by raw-extract Centella asiatica (RECA) could be due to the presence of the abundant terpenoids, polyphenol, flavonoid, β-carotene, tannin, Vitamin C, and DPPH compounds found in this plant [50]
Summary
Alzheimers disease (AD) is a progressive, debilitating and heterogeneous neurological disorder, which is characterized clinically by memory loss, impaired cognitive functions and inappropriate behaviour that serious enough to impose severe strains on the social welfare systems The etiopathogenesis of this disease is multifactorial and recent evidence demonstrates that the deficits in central cholinergic neurotransmission in the brain, inflammatory injury and induction of oxidative stress interrelated on progression of AD [1], [2]. The development of strategies for reducing inflammation and oxidation level could open up new window into effective treatments for these diseases By keeping this as a key factor, some herbal products containing biological active molecules could participate as a substitute for allopathic medicine [14]. This study is mainly devoted to finely evaluate the effect of C.asiatica extract designated as raw-extract Centella asiatica (RECA), in ameliorating the AChE, neuroinflammation and oxidative stress on lipopolysaccharides-induced Sprague Dawley rats’ model
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Engineering & Technology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
