Abstract
This review identifies specific cardiotoxicity related to anthracycline chemotherapy, specific risk factors related to increased anthracycline chemotherapy-induced cardiotoxicity, and underlying mechanisms of action of anthracycline chemotherapy-induced cardiotoxicity. PubMed®, CINAHL®, Embase®, and Web of Science were searched in May 2018 using keywords related to heart diseases, anthracycline chemotherapy, and breast cancer. Data were extracted, and study quality was assessed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. 1,117 articles were identified through the literature search. After a review of the abstracts and articles, 15 clinical studies were identified for the final analysis by using exclusion and inclusion criteria. Nurses should recognize the critical elements for prevention and early detection of anthracycline chemotherapy-induced cardiotoxicity.
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