Annular telangiectatic perivascular angiomatosis: a paradoxical adverse event of propranolol

Abstract

Funding sources: none. Conflicts of interest: none declared. Dear Editor, An 83‐year‐old woman presented with a 4‐month history of asymptomatic annular lesions, with disseminated distribution except for the face and distal part of the extremities. They were characterized by erythemato‐violaceous and somewhat hyperpigmented, annular plaques with central clearing and radial telangiectasias (Fig. 1). These were sharply demarcated, slightly raised with a smooth surface. The diameter ranged between 3 and 8 cm. Her past medical history included hypertension for the previous 12 years, controlled with propranolol 100 mg daily for the last 5 years. One biopsy from the chest and another from the left lumbar area were obtained. Histology in both revealed a superficial, mid and deep perivascular angiomatous proliferation with a glomerulus‐like appearance (Fig. 2) and absent inflammatory infiltrate. Some dilated bloodless vessels were present in the superficial and mid‐reticular dermis. The epidermis and adnexa were normal. Immunohistochemistry for CD34 was performed, with positive staining.