Abstract
Barrier function is critical for epithelial tissues. Epithelial cells maintain barrier function via tight junctions, which must be remodeled to allow for cell- and tissue-scale shape changes. How barrier function is maintained and remodeled as epithelial cells change shape remains unclear.The scaffolding protein Anillin is required for generating effective actomyosin contraction to reinforce damaged tight junctions; lack of reinforcement leads to repeated barrier leaks.These findings highlight a novel role for Anillin in tight junction remodeling and suggest that Anillin's ability to tune the level and duration of local Rho activation affects the contractile output.
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