Abstract
Angiopoietin-like 4: An endogenous break of intestinal lipid digestion
Highlights
Obesity is characterized by excessive adipose tissue mass and cause for a variety of pathologic conditions like cardiovascular disease, type 2 diabetes and cancer [1]
While small portions of ingested lipids are hydrolyzed by lingual lipase and gastric lipase in the stomach, the vast majority of ingested TAGs are metabolized in the small intestine. There they are emulsified by bile acids and hydrolyzed by the action of pancreatic lipase (PL), co-lipase, PL-related protein 2, and carboxyl ester lipase [1,2]
The resulting free fatty acids (FFA) and monoacylglycerols are subsequently taken up by enterocytes, re-esterified to TAGs, packed into chylomicrons and released into the lymphatic system where they enter the circulation via the thoracic duct
Summary
Obesity is characterized by excessive adipose tissue mass and cause for a variety of pathologic conditions like cardiovascular disease, type 2 diabetes and cancer [1]. Dietary fats mostly composed of mixed triacylglycerols (TAGs) are processed in the digestive tract by extracellular lipases. While small portions of ingested lipids are hydrolyzed by lingual lipase and gastric lipase in the stomach, the vast majority of ingested TAGs are metabolized in the small intestine.
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