Abstract
Angioarchitecture was investigated by using scanning electron microscopy of microcorrosion casts in 12 hydrocephalic rats and 5 normal control rats to observe changes in the vascular bed of the cerebral mantle in hydrocephalus. Hydrocephalus was induced by infusion of kaolin into the cisterna magna using puncture through the occipital bone. After injecting polyester resin into the brain vessels from the aortic arch, the head was cut into serial sagittal sections close to the midline to observe the ventricle size. Among the hydrocephalic rats, two showed advanced ventricular size and 10 moderate. Brain tissue, dura mater, cranium and muscle were corroded together to prevent destruction of the microvascular casts. Reduction in the number and caliber of the capillaries in the white matter was the most remarkable change in the hydrocephalic rats. This change increased in proportion to the severity of hydrocephalus. Similar changes were observed in the basal ganglia. Changes in the cortical capillaries were mild, but cortical “palisade” patterns disappeared in some hydrocephalic cases. The crossing and pressing phenomena of the white matter vessels were characteristic, and not seen in the control rats. Three dimentional consideration of the angioarchitecture by using microvascular casts in rat hydrocephalus is discussed, compared with the m icroan gio graphic techniques.
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