Abstract
Background: Endoscopic retrograde cholangiopancreatography (ERCP) has been one of the most intensely studied endoscopic procedures due to its overall high complication rates when compared to other digestive endoscopy procedures. The safety and outcome of such procedures have been linked to multiple procedure- or patient-related risk factors. The aim of our study is to evaluate whether the morphology of the major duodenal papilla influences the ERCP outcomes and complication rates. Methods: A total of 322 patients with a native papilla have been included in the study over an eight month period. Morphology of the papilla has been classified into normal papilla and four anatomical variations (Type I-IV). All patients have been prospectively monitored over a 15 day period after ERCP. Procedural outcomes and complication rates have been registered. Results: Morphology of the papilla influences both overall complication rates (95%CI, p = 0.0066) and post-ERCP pancreatitis rates (95%CI, p = 0.01001) in univariate analysis. Type IV papillae have proven to be independent risk factors for post-ERCP pancreatitis in multivariate analysis (OR = 12.176, 95%CI, p = 0.005). Type I papillae have been significantly linked to difficult cannulation (AUC = 0.591, 95%CI, p = 0.008); Conclusions: In the monitored cohort morphology of the major duodenal papilla has significantly influenced both ERCP outcomes and post-procedural complication rates.
Highlights
The first anatomical description of the major duodenal papilla was published during the late 19th century within the Hunterian Lectures [1] and it has since been a multidisciplinary issue debated by anatomists, radiologists, surgeons and gastroenterologists
For digestive endoscopists it has played an important role in developing techniques for endoscopic retrograde cholangiopancreatography (ERCP), as cannulation of the papilla is essential for the success of such procedures
Acquiring the skills for a safe and successful bile duct cannulation is an essential step for the overall efficiency of the procedure [2,3], as difficulties in cannulation have often been linked to post-Endoscopic retrograde cholangiopancreatography (ERCP) adverse events or poor outcomes [4,5]
Summary
The first anatomical description of the major duodenal papilla was published during the late 19th century within the Hunterian Lectures [1] and it has since been a multidisciplinary issue debated by anatomists, radiologists, surgeons and gastroenterologists. For digestive endoscopists it has played an important role in developing techniques for endoscopic retrograde cholangiopancreatography (ERCP), as cannulation of the papilla is essential for the success of such procedures. Type I papillae have been significantly linked to difficult cannulation (AUC = 0.591, 95%CI, p = 0.008); Conclusions: In the monitored cohort morphology of the major duodenal papilla has significantly influenced both ERCP outcomes and post-procedural complication rates
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