Anatomical observations on the dorsal column nuclei, their thalamic projection and the cytoarchitecture of some somatosensory thalamic nuclei in the monkey.

Abstract

AbstractThe results of the present anatomical study on macaque monkeys concern some aspects of the dorsal column nuclei, their projection to the thalamus and the cytoarchitecture and topography of the recipient areas in the thalamus for the somatosensory pathways. Some observations regarding the cytoarchitecture of the dorsal column nuclei are reported; the gracile nucleus differs cytoarchitectonically over the rostrocaudal dimension in a way similar to the feline nucleus; the cuneate nucleus has a distinct pars rotunda (Ferraro and Barrera, '35) which might be analogous to a similar structure in the raccoon shown to be activated by afferents from the volar side of the hand and digits (Johnson et al., '68). Cytoarchitectonic observations and other arguments suggesting the presence of the nucleus Z in the monkey are presented.In Nissl stained frontal sections, cut in the stereotaxic frontal plane as well as in sections cut perpendicular to the long axis of the brain stem the cytoarchitecture and topography of the posteromedial, ventroposterior and centrolateral thalamic nuclei of the macaque were analysed. The posteromedial nucleus (POm) has been found to include portions of Olszewski's ('52) magnocellular medial geniculate, suprageniculate and pulvinar nuclei. The nucleus ventralis posterolateralis (VPL) corresponds to the main portion of Olszewski's VPLc, whereas most of his VPLo corresponds to the nucleus ventralis intermedius of Hassler ('59) and Mehler ('71).Electrolytic lesions were used to study the projection from the gracile and cuneate nuclei to the thalamus. With postoperative survival periods of 6 to 14 days the resulting degeneration was studied in frontal sections stained according to the Wiitanen modification of the Fink‐Heimer method. Both the gracile and cuneate nuclei project profusely to the contralateral nucleus ventralis posterolateralis and more sparsely to the contralateral posteromedial nucleus and the zona incerta. A distinct somatotopic organization exists in the projection to the ventroposterior nucleus, but not in that to the other target areas. The projection to the ventroposterior nucleus is very dense and evenly distributed except rostrally and dorsally, where it is more scattered.It is concluded that the posteromedial and the ventroposterior thalamic nuclei are very similar in monkeys and cats regarding cytoarchitecture, topography and afferent projections from the dorsal column nuclei.