Abstract
•The aim of this work was to develop the methods of determination for phenol derivatives: bisphenol A (BPA), 4-tert-octylphenol (OP) and 4-nonylphenol (NP), in the whole body of herring Clupea harengus and in physiological fluids of the Baltic grey seal Halichoerus grypus grypus (blood and milk).•Methods were based on liquid chromatography coupled with a fluorescence detector (HPLC-FL).•These methods were satisfactorily validated, each showing good recovery (>80%) and precision (RSD?<?15%). Regarding the limit of quantification (LOQ), this was established at <2 ng?g-1 for herring, <0.07 ng?cm-3 for blood and <0.1 ng?cm-3 for milk.
Highlights
Methods were based on liquid chromatography coupled with a fluorescence detector (HPLC-FL)
The aim of the conducted research was to develop a method allowing to determine at one analysis the concentrations of bisphenol A, 4-tert-octylphenol and 4-nonylphenol in biological tissues
The methods developed in this work were applied to investigate the presence of selected contaminants: bisphenol A (BPA), 4-tert-octylphenol (OP) and 4-nonylphenol (NP) in the whole body of herring and in physiological fluids of the Baltic grey seal Halichoerus grypus
Summary
Methods were based on liquid chromatography coupled with a fluorescence detector (HPLC-FL). ARTICLE INFO Method name: Determination of bisphenol A, 4-tert-octylphenol and 4-nonylphenol in whole fish, blood and milk samples by HPLC-FL Keywords: Phenol derivatives, Biological samples, Liquid chromatography, Fluorescence detector Article history: Received 1 August 2018; Accepted 18 September 2018; Available online 21 September 2018
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