Abstract
Women have metabolic, immunological, and genetic variables that ensure more protection from coronavirus infection. However, the indication of treatment for several pathologies and contraception is determined by hormones that have adverse effects and raise doubts about their use during the COVID-19 pandemic. Therefore, the present study searches women specificities and the relation between female sexual hormones and COVID-19, and reports the main recommendations in this background. To this end, a review of the literature was conducted in the main databases, auxiliary data sources, and official websites. Therefore, considering the hypercoagulability status of COVID-19, the debate about the use of contraceptives due to the relative risk of thromboembolic effects that they impose arises. However, the current available evidence, as well as the recommendations of main health organs around the world, demonstrate that the use of hormonal contraceptives must be maintained during the pandemic.
Highlights
Coronavirus is a disease with high transmissibility and mortality, with 15,785,641 confirmed cases around the world accumulated until July and, in Brazil, a total of 2,343,366 cases according to the World Health Organization (WHO).[1]
It is perceived that women who make use of COC present resistance to Creactive protein (CRP), whose effect may be related to the disturbance of sex hormone binding globulin (SHBG) induced by different classes of progestogens
Based on female-specific sexual characteristics such as higher expression of ACE2 and TLR7 due the additional chromosome X, as well as on the tissue protection and broad anti-inflammatory action of progesterone and estrogen, it is well-known that women should be analyzed from a particular perspective regarding COVID-19
Summary
Coronavirus is a disease with high transmissibility and mortality, with 15,785,641 confirmed cases around the world accumulated until July and, in Brazil, a total of 2,343,366 cases according to the World Health Organization (WHO).[1]. Thereby, some of the factors that can influence in the differences between genders are determined by metabolic, genetic, and immunological variables, and studies demonstrate that these mechanisms provide more protection to women.[3] the main features in the treatment of pathologies or in contraception must be critically analyzed when facing the pandemic. With social isolation, health services have their attendance adapted to a reality of social isolation, which does not allow integral monitoring to the needs of women.[4] In addition, the indication of treatment for some pathologies and contraception are determined by hormones that have side effects and raise doubts about the right use when facing COVID-19.5 the present study aims at investigating the main variables of females, such as the relation between female sexual hormones and COVID-19, as well as at reporting alternatives for the rational use of contraceptives in the pandemic background
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
