Abstract
Objectives: There is a high rate of sudden death in epilepsy patients, part of which is sudden cardiac death. By investigating ECG T wave alternans and Q-T dispersion changes of epilepsy patients, we may predict the possibility of the occurrence of sudden death and provide basis for clinical prevention. Methods: Selecting 587 cases of epilepsy patients as the study group, 672 same period cases of healthy persons as the control group; Analyzing the effect of epilepsy on ECG T wave alternans and Q-T dispersion with the standard 12 lead ECG. Results: The study group had a significantly prolonged Q-T dispersion and an increased incidence of T wave alternans than that of the control group; Compared with other seizure types, tonic clonic seizure and absence seizure had a significantly prolonged Q-T dispersion and an increased occurrence rate of T wave alternans. Conclusions: Epilepsy patients ECG T wave alternans and Q-T dispersion has higher abnormal rate, and are prone to sudden cardiac death; Routine ECG(RECG) T wave alternans and Q-T dispersion changes can provide guidance for clinical prevention of sudden unexpected death in epilepsy (SUDEP).
Highlights
Sudden unexpected death in epilepsy is an unexplained death that occurs to epilepsy patients without the prior expectations, with or without witnesses, non trauma or drowning cases; it may be associated or not associated with seizures, except status epilepticus, no autopsy lethal toxicity and anatomical factors [1]
By investigating ECG T wave alternans and Q-T dispersion changes of epilepsy patients, we may predict the possibility of the occurrence of sudden death and provide basis for clinical prevention
We analyzed the changes of T wave alternans and Q-T dispersion (QTd) in RECG of epilepsy patients who were diagnosed in our hospital from January 2011 to December 2015, as to provide early prediction index for the prevention of sudden death in epilepsy; and it is reported as follows
Summary
Sudden unexpected death in epilepsy is an unexplained death that occurs to epilepsy patients without the prior expectations, with or without witnesses, non trauma or drowning cases; it may be associated or not associated with seizures, except status epilepticus, no autopsy lethal toxicity and anatomical factors [1]. SUDEP is the fatal complication of epilepsy, accounting for 7.5% - 17% of death in patients with epilepsy [2]. Causes of SUDEP are quite complex, of which part. L. Cheng 110 of the patient is sudden cardiac death. The main cause of sudden cardiac death is ventricular arrhythmia, especially ventricular fibrillation, while the exception of T wave alternans and Q-T dispersion is extremely easy to cause ventricular fibrillation. We analyzed the changes of T wave alternans and Q-T dispersion (QTd) in RECG of epilepsy patients who were diagnosed in our hospital from January 2011 to December 2015, as to provide early prediction index for the prevention of sudden death in epilepsy; and it is reported as follows
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