Analysis of the Efficacy of Humidified High-Flow Nasal Oxygen Therapy Combined with Alveolar Lavage in the Treatment of Patients with Severe Pneumonia Complicated with Respiratory Failure

Abstract

Objective: To analyze the curative effect of humidified high-flow nasal oxygen therapy combined with alveolar lavage in patients with severe pneumonia and respiratory failure. Methods: 120 patients with severe pneumonia complicated with respiratory failure admitted to the Third People’s Hospital of Xining from July 2021 to December 2022 were randomly divided into two groups: group A and group B. The patients in group A were given humidified high-flow nasal oxygen therapy combined with alveolar lavage, whereas those in group B were given humidified high-flow nasal oxygen therapy. The treatment efficacy, blood gas analysis results, and differences in inflammatory mediators were compared between the two groups. Results: The curative effect in group A (96.67%) was significantly higher than that in group B (81.67%), P < 0.05; the partial pressure of carbon dioxide (PaCO2), partial pressure of oxygen (PaO2 ), oxygen saturation (SpO2 ), and Horowitz index (P/F) of group A were significantly better than group B, P < 0.05; the interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and C-reactive protein (CRP) levels, white blood cell (WBC) count, serum procalcitonin (PCT), and neutrophil (N) percentage of group A were significantly lower than those of group B, P < 0.05. Conclusion: For patients with severe pneumonia complicated with respiratory failure, alveolar lavage, on the basis of humidified high-flow oxygen therapy, can inhibit local inflammation, improve blood gas analysis results, promote disease recovery, and improve the clinical treatment effect.