Abstract
4-amino pyridine, given by intra-arterial injection towards the lumbar region of the cord of the spinal cat, exhibited a powerful convulsive action on this structure. Dorsal and ventral discharges appeared, accompanied by rhythmic fluctuations of the polarisation of the afferent fibre terminals. This substance did not modify specifically the phenomena of postsynaptic inhibition. In contrast, the dorsal root potentials and the post-tetanic potentiation of the discharges of monosynaptic origin were considerably altered. These last two properties were attributed to partial depolarisation of the afferent fibre terminals.
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