Abstract
The effect of morphine and trimeperidine on the concentration, uptake, and liberation of noradrenalin (NA) in the rat myocardium was investigated. Trimeperidine lowers the NA level in the myocardium. Morphine does not affect the liberation of NA-14C from the isolated perfused heart, whereas trimeperidine significantly increases it, affecting both the “slow” and the “rapid” release of the mediator. Trimeperidine does not affect the uptake of NA-14C by the perfused heart but morphine significantly lowers it. Competition between morphine and NA is characterized by an incomplete inhibition effect: Morphine and NA mutually affect the affinity of each other for the receptor and their interaction depends on their relative concentrations.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
