Analysis of the effect and safety of atorvastatin in the treatment of septic shock

Abstract

Objective To explore the clinical efficacy and safety of atorvastatin in the treatment of patients with septic shock.Methods 67 patients with septic shock were randomly divided into the treatment group （34 cases） and control group（33 cases）.The control group was treated with conventional therapy ,and the observation group was administered with atorvastatin based on the control group .Before and after treatment ,the inflammatory index ,cytokines levels,the number of MODS cases,the number of deaths at 28th day,and the incidence of adverse reactions were com-pared between the two groups .Results The heart rate ,respiratory rate ,white blood cell count of the treatment group were significantly better than the control group ,the cytokines levels were significantly lower than the control group ,the differences were statistically significant （t=4.181,3.622,4.879,all P〈0.05）.The incidence rate of MODS of treat-ment group was significantly lower than that of the control group （χ2 =7.153,P〈0.05）.The average hospital stay of the treatment group was （9.3 ±3.1）d,which was significantly less than （12.4 ±3.3）d of the control group（t=3.964,P〈0.05）.The incidence rate of adverse reaction in the treatment group was significantly lower than that of the control group（χ2 =4.566,P〈0.05）.The 28 d mortality rate of the two groups had no significant difference （χ2 =3.345,P〉0.05）.Conclusion Atorvastatin can effectively reduce the degree of inflammatory reaction in patients with septic shock ,decrease the incidence of MODS , and has potential benefits on the prognosis of patients , but still need to be further confirmed by clinical research . Key words: Shock; Infection; Atorvastatin