Abstract

AbstractBackgroundThe Addenbrooke's Cognitive Examination‐Revised (ACE‐R) is a brief yet reliable test battery that provides evaluation of six cognitive domains (orientation, attention, memory, verbal fluency, language and visuospatial ability) and widely used to measure cognition. It was developed and revised to provide a brief test sensitive to the early stages of dementia, and is also effective for differentiating the subtypes of dementia, such as Alzheimer’s disease, frontotemporal dementia, progressive supranuclear palsy, and other forms of dementia associated with parkinsonism. Our objective was to identify which sub‐items of ACE‐R could differentiate health controls, amMCI and non‐amMCI.MethodData originated from Brazilian Aging Memory Study (BRAMS).110 subjects: health controls (HC) (n=22; age 73.6±6y; schooling 14±4y; 77.2% female), amnestic MCI (amMCI) patients (n=64; age 73±6y; schooling 11±5y; 81.2% female) and non‐amnestic (non‐amnMCI) patients (n=24; age 70±7y; schooling 12±45y; 83.3% female) assessed by neurological exam and neuropsychological assessment. The Brazilian version of ACE‐R was applied as part of the cognitive assessment in all participants, but was not used to determine diagnosis.ResultThe following items differentiated between HC and amMCI: 3‐words recall (p=0.04), name/address recall (p=0.02), Verbal Fluency Letter P (p=0.01) and Verbal Fluency Animals (p<0.01); No differences were found between HC and non‐amMCI and non‐amMCI and amMCI.ConclusionIdentifying sub‐items that best differentiates groups could add more information to the clinician regarding the diagnosis and progression of the disease.

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